I was successfully using my Pro-100 while on MacOS Mojave. Now, I'm NOT SURE if this is what did it, but recently I upgraded to MacOS Big Sur. When I went to print for the first time since upgrading, all my color profiles were gone. The one it chose by default ("Academy" something) gave terrible results (too dark).
I went to the Canon website and reinstalled the driver for MacOS 12. Note: under MacOS Big Sur, it said there was no driver.
Solved! Go to Solution.